Cisplatin transporter

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August undefined, 2024

WebJul 1, 2024 · The remaining cisplatin can transport to tumor cells by passive diffusion through plasma membrane [31], [44], [47]. Modern studies reveal that copper transporter protein CTR1 is also responsible for cisplatin uptake [48]. Cisplatin causes degradation of concentration of CRT1, resulting in lower cisplatin accumulation by the cancer cells. WebSep 6, 2012 · Cisplatin is a potent cytostatic drug, whose use is limited by its severe acute and chronic nephro-, oto-, and peripheral neurotoxicity. For this reason, other platinum derivatives, such as carboplatin and oxaliplatin, with less toxicity but still with antitumoral action have been developed.

Organic Cation Transporter 2 - an overview ScienceDirect Topics

WebFeb 23, 2007 · Ctr1, the major copper influx transporter, has been convincingly demonstrated to transport cisplatin and its analogues, carboplatin, and oxaliplatin. … WebThese transporters have a large binding site containing partially overlapping interaction domains for different substrates and are specifically distributed around the body. … shapes 1 2 and 1 2 not aligned

MATE1 - Transporters - Solvo Biotechnology

WebCisplatin is mainly internalised by the copper transporter CTR1. Accordingly, CTR1 down-regulation has been associated with resistance to platinum-based drugs in cancer [ 10 , 11 ]. Cellular inactivation of cisplatin and subsequent sequestration can be mediated by binding to cytoplasmic nucleophilic factors, including glutathione (GSH) and ... WebApr 14, 2024 · HIGHLIGHTS. who: ICP-TOF et al. from the Autonomous University of Madrid, Spain have published the research: The copper transporter CTR1 and cisplatin … WebJul 22, 2009 · Organic cation transporter 2 (OCT2) has been implicated in the cellular uptake of cisplatin, but its role in cisplatin-induced nephrotoxicity remains unknown. In mice, deletion of Oct1 and Oct2 resulted in significantly impaired urinary excretion of cisplatin without an apparent influence on plasma levels. pony linebacker trainers

The copper transporter ctr1 and cisplatin accumulation at the …

Uptake of the anticancer drug cisplatin mediated by the …

WebJul 3, 2024 · Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for this toxicity has not been … WebFeb 10, 2024 · Cisplatin is a chemotherapeutic drug widely used to treat various types of cancers, including testicular, ovarian, bladder, head and neck, lung, and cervical cancers. However, patients treated with cisplatin frequently suffer from nausea, vomiting, fatigue, serious kidney problems, tinnitus and hearing loss. shapes 1 4 and 1 4 not alignedWebFeb 23, 2007 · Ctr1, the major copper influx transporter, has been convincingly demonstrated to transport cisplatin and its analogues, carboplatin, and oxaliplatin. Evidence also suggests that the two copper efflux transporters ATP7A and … shapes 128 1 and 128 10 are incompatible

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Cisplatin transporter

An Updated View of Cisplatin Transport - Arnesano - 2013

WebCisplatin, or cis-diamminedichloridoplatinum(II) cis-[PtCl 2 (NH 3) 2], is a platinum-based anticancer drug largely used for the treatment of various types of cancers, including … WebApr 14, 2024 · HIGHLIGHTS. who: ICP-TOF et al. from the Autonomous University of Madrid, Spain have published the research: The copper transporter CTR1 and cisplatin accumulation at the single-cell level by LA-ICP-TOFMS, in the Journal: (JOURNAL) what: In this study, total CTR1 levels (comprising plasma_membrane-associated and intracellular …

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WebApr 24, 2015 · Cisplatin seems to interact preferentially with hOCT2 (Ciarimboli et al., 2005), suggesting that hOCT2 is the critical transporter for renal cisplatin uptake in … WebApr 30, 2015 · Cisplatin is one of the first-line platinum-based chemotherapeutic agents for treatment of many types of cancer, including ovary cancer. CTR1 (copper transporter 1), a transmembrane solute carrier transporter, has previously been shown to increase the cellular uptake and sensitivity of cisplatin. It is hypothesized that increased CTR1 …

WebDec 14, 2024 · Cisplatin (CDDP) is a chemotherapy drug commonly used in systemic treatment of germ cell tumors, including cancers of the ovaries, testes, and solid tumors of the head and neck 1. WebSep 6, 2012 · Cisplatin is a potent cytostatic drug, whose use is limited by its severe acute and chronic nephro-, oto-, and peripheral neurotoxicity. For this reason, other platinum …

WebCisplatin triggers rapid degradation of Copper Transporter 1, reducing influx of cisplatin and increasing resistance to it. Explore the transporter in PDB ID 6m97 . Glutathione transferase (GST) P1-1 is a cisplatin-binding protein that can inactivate cisplatin. WebApr 5, 2024 · Cisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It remains an important and effective therapy in many forms of cancer today. Cisplatin mediates its tumorcidal effects via a number of different cytotoxic mechanisms. Although it is best known for DNA damage, cisplatin also causes cytoplasmic organelle …

WebEffects of siRNA-GLUT-1 and LY294002 on apoptosis and cell cycle in Hep-2 cells after treatment with cisplatinBefore the cisplatin treatment, the apoptotic rates of cells in the siRNA-GLUT-1 and LY294002 groups were increased markedly at 24 hours and 48 hours compared with the Hep-2 cell and siRNA-NC groups (P<0.05; Figure 2).The early …

WebMay 11, 2012 · Cisplatin is a prescription medicine used alone to treat bladder and ovarian cancer.It is also used together with other drugs to help treat testicular cancer, locally … shapes 1 3 and 4 not aligned: 3 dim 1 4 dim 0WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … shapes 18 9 and 18 9 not alignedWebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in … pony line four seasonsWebFeb 28, 2024 · However, the principal mechanisms by which 13 and, above all, 18 overcome cisplatin resistance rely on three different possible mechanisms: the inhibition of endogenous P-gp expression, a transporter that enables the active efflux of the drug from the cancer cells; the generation of ROS inside the cells that can reduce GSH levels, a … shapes 1 3 and 1 3 not alignedWebAug 1, 2016 · Cisplatin Pazopanib Renal transporters OCT-2 Drug-drug interaction 1. Introduction Angiogenesis inhibitors represent a promising approach in the treatment of … shapes 1 5 and 4 not aligned: 5 dim 1 4 dim 0WebThe direction of MATE1 transport is defined by the proton concentration gradient: when assayed in vitro at pH 7.4 or higher, MATE1 behaves as an uptake transporter, whereas … shapes 200 10 2 and 200 10 are incompatibleWebThe copper transporter 1 seems to be of particular importance for cisplatin uptake in tumor cells, while the organic cation transporter (OCT) 2, due to its specific organ distribution, may play a major role in the development of undesired cisplatin side effects. pony lights